Solstice Intelligence Reports

Published Intelligence

Each report begins with 100,000 adversarial AI perspectives across 8 worldviews, tested through multi-round crucible debate, then grounded against published literature from PubMed, Semantic Scholar, ClinicalTrials.gov, and Europe PMC.

479K+
Total Perspectives
1,376
Papers Retrieved
113
Claims Tested
5/5
Survived Falsification
🧬

Metformin & Longevity

February 27, 2026 — Week 1
Is metformin's longevity effect real, or a concentration artifact? 100K perspectives converge on AMPK activation as primary mechanism, but the evidence engine reveals a significant overclaiming gap.
80%
Convergence Confidence
100K
Perspectives
303
Papers Found
21
Claims Tested
Survived
Falsification
🧠

SSRI Therapeutic Delay

February 27, 2026 — Week 1
Why do SSRIs take 2–6 weeks to work if serotonin changes happen in hours? 100K perspectives converge on downstream neuroadaptive changes — not serotonin itself — as the therapeutic mechanism.
85%
Convergence Confidence
100K
Perspectives
188
Papers Found
21
Claims Tested
Survived
Falsification
🧠

SSRI Therapeutic Delay v2 2022-2025

March 3, 2026 — Week 2
Updated with 2022–2025 evidence: Johansen 2023 PET synaptic density, Kot 2024 NMR TrkB binding, Nichols 2023 180x membrane accumulation, Boschloo 2023 temporal dissociation (n=8,262). Convergence overclaimed by 74% — high internal agreement but low external grounding.
82%
Convergence Confidence
79K
Perspectives
190
Papers Found
20
Claims Tested
Partial
Falsification
🔬

Alzheimer's & the Amyloid Hypothesis

February 27, 2026 — Week 1
30 years and $42B spent on amyloid. Was it the right target? 100K perspectives converge on tau pathology and neuroinflammation as the primary drivers — amyloid is a consequence, not a cause.
80%
Convergence Confidence
100K
Perspectives
281
Papers Found
20
Claims Tested
Survived
Falsification
🩺

Autoimmune Disease & Gut-Immune Axis

February 28, 2026 — Week 1
Why are autoimmune diseases exploding in industrialized nations? 100K perspectives converge on disrupted immune homeostasis linked to intestinal permeability — the gut-immune axis is the common thread.
80%
Convergence Confidence
100K
Perspectives
414
Papers Found
31
Claims Tested
Survived
Falsification

Methodology

Convergence Engine

100,000 adversarial AI perspectives across 8 worldviews (Western Biomedical, Traditional Medicine, Systems Biology, Evolutionary, Microbiome, Pharmacology, Neuroscience, Clinical). Finds where diverse analytical frames agree.

Crucible Debate

3 rounds of adversarial attack/defense with confidence scoring. A neutral judge evaluates surviving arguments, destroyed claims, and final verdict. Only consensus that survives hostile scrutiny makes the report.

Evidence Engine

Every claim is tested against real published literature from PubMed, Semantic Scholar, ClinicalTrials.gov, and Europe PMC. Evidence pyramid scoring weights systematic reviews highest. Active falsification attempts to break findings.

These reports are AI-generated research analysis. They are not medical advice, investment advice, or peer-reviewed publications. The convergence engine synthesizes AI perspectives — not human expert opinion. Evidence grounding uses automated literature retrieval and classification. Always consult qualified professionals before making decisions based on these findings.